Selected Media

Cognitum Episode 9 // Cancer as a Metabolic Disease
Cognitum {}
March 20, 2019

Challenging Conventional Cancer Care with Dr. Thomas Seyfried – PH97
Julie Foucher
October 16, 2018

Peak Human
Part 35 – Dr. Thomas Seyfried on Cancer as a Metabolic Disease, More Effective Therapies, and Treating it Without Toxicity
April 2, 2019

More media

Selected Presentations

Press-Pulse: A Novel Strategy for the Metabolic Management of Cancer
Epigenix Foundation
Published: November 14, 2017

A Novel Therapeutic Strategy For Metabolic Management of Cancer – Thomas Seyfried
Silicon Valley Health Institute
Published: July 13, 2018

Cancer as a Metabolic Disease with Dr. Thomas Seyfried
Hyperbaric Medical Solutions
Published: November 14, 2016

More presentations


You can make a donation to The Foundation for Metabolic Cancer Therapies, a 501(c)(3) organization, to support Dr. Seyfried’s work.

If you would like to show your support for the research Dr. Seyfried and his lab undertake, you can easily contribute a donation through the Boston College page. Please make sure that you specify ‘Dr. Seyfried and his lab’ under the ‘I wish to make my gift to’ section by selecting the ‘other’ category and filling in this information. Please specify that your gift is to be considered “very exclusive” and that the entire gift is to be used only for Dr. Seyfried’s cancer research. Contributions of any size are welcome. [source: Boston College]


Dr. Seyfried published a groundbreaking treatise entitled, Cancer as a Metabolic Disease: On the Origin, Management, and Prevention of Cancer (Wiley, 1st ed., 2012). The treatise provides extensive information showing that cancer can be best defined as a mitochondrial metabolic disease rather than as a genetic disease. This new concept has implications for the development of new non-toxic cancer therapies including the ketogenic diet. Experts in the cancer research field have praised this comprehensive study as one of science’s hottest topics. [Source: Boston College]


Our research program focuses on mechanisms by which metabolic therapy manages chronic diseases such as epilepsy, neurodegenerative lipid storage diseases, and cancer. The metabolic therapies include caloric restriction, fasting, and ketogenic diets. Our approach is based on the idea that compensatory metabolic pathways are capable of modifying the pathogenesis of complex diseases. Global shifts in metabolic environment can neutralize molecular pathology. In the case of cancer, these therapies target and kill tumor cells while enhancing the physiological health of normal cells. The neurochemical and genetic mechanisms of these phenomena are under investigation in novel animal models and include the processes of inflammation, cellular physiology, angiogenesis, and lipid biochemistry. [Source: Boston College]

Selected Publications

Chinopoulos, Christos, and Thomas N. Seyfried. “Mitochondrial Substrate-Level Phosphorylation as Energy Source for Glioblastoma: Review and Hypothesis.” ASN Neuro, Jan. 2018, doi:10.1177/1759091418818261.

Elsakka, A.M.A., Bary, M.A., Abdelzaher, E., Elnaggar, M., Kalamian, M., Mukherjee, P., Seyfried, T.N., 2018. Management of Glioblastoma Multiforme in a Patient Treated With Ketogenic Metabolic Therapy and Modified Standard of Care: A 24-Month Follow-Up. Front Nutr 5, 20. https://doi.org/10.3389/fnut.2018.00020

Seyfried, T.N., Yu, G., Maroon, J.C., D’Agostino, D.P., 2017. Press-pulse: a novel therapeutic strategy for the metabolic management of cancer. Nutrition & Metabolism 14, 19. https://doi.org/10.1186/s12986-017-0178-2

More publications


Thomas N. Seyfried received his Ph.D. in Genetics and Biochemistry from the University of Illinois, Urbana, in 1976. He did his undergraduate work at the University of New England, where he recently received the distinguished Alumni Achievement Award. He also holds a Master’s degree in Genetics from Illinois State University. Thomas Seyfried served with distinction in the United States Army’s First Cavalry Division during the Vietnam War and received numerous medals and commendations. He was a Postdoctoral Fellow in the Department of Neurology at the Yale University School of Medicine and then served on the faculty as an Assistant Professor in Neurology.

Other awards and honors have come from such diverse organizations as the American Oil Chemists Society, the National Institutes of Health, The American Society for Neurochemistry, the Ketogenic Diet Special Interest Group of the American Epilepsy Society, the Academy of Comprehensive and Complementary Medicine, and the American College of Nutrition.

Dr. Seyfried previously served as Chair, Scientific Advisory Committee for the National Tay-Sachs and Allied Diseases Association and presently serves on several editorial boards, including those for Nutrition & Metabolism, Neurochemical Research, the Journal of Lipid Research, and ASN Neuro, where he is a Senior Editor.

Dr. Seyfried has over 150 peer-reviewed publications and is the author of the book, Cancer as a Metabolic Disease: On the Origin, Management, and Prevention of Cancer (Wiley, 1st ed., 2012).